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血清甘胆酸与总胆汁酸联合检测在妊娠肝内胆汁淤积症的应用
作者:王金华?
单位:大连市妇女儿童医疗中心检验科?辽宁?大连?116037?
关键词:甘胆酸?总胆汁酸?妊娠肝内胆汁淤积症?
分类号:R 714.14
出版年,卷(期):页码:2019,36(4):381-382
摘要:

摘要:目的 分析血清甘胆酸(CG)与总胆汁酸(TBA)联合检测妊娠肝内胆汁淤积症(ICP)的应用价值。方法 选择2016年5月~2018年4月我院收治的65例ICP患者为观察组,轻度ICP 40例,重度ICP 25例;选择同期65例健康孕产妇列为对照组。比较观察组、对照组及不同ICP病情程度患者血清TBA、CG水平;不同ICP病情程度患者并发症发生情况。结果 观察组血清TBA、CG水平分别高于对照组,两组差异均有统计学意义(均P<0.05)。重度ICP组血清TBA、CG水平分别高于轻度ICP组,两组差异均有统计学意义(均P<0.05)。重度ICP组的并发症发生率为36.0%,高于轻度ICP组的15.0%,差异有统计学意义(P<0.05)。在ICP诊断中,CG+TBA诊断的阳性率、敏感度、特异性最高,分别为95.8%、98.5%、92.3%。相较于健康妊娠人群,ICP患者的血清TBA、CG明显增高,其中重度ICP患者增高最为明显,且重度ICP患者的妊娠结局多不良。结论 对孕产妇常规开展血清TBA、CG联合筛查,有助于ICP的诊断和病情的评估,对临床诊治意义重大。
关键词:甘胆酸;总胆汁酸;妊娠肝内胆汁淤积症

Abstract:Objective To analyze the application value of serum cholic acid (CGG) and total bile acid (TBA) in the detection of intrahepatic cholestasis of pregnancy(ICP). Methods 65 patients with ICP from May 2016 to April 2017 were selected as observation group, including 40 mild ICPs and 25severe ICPs, and 65 healthy pregnant women were selected as control group. The serum levels of ICP in the control group and the patients with different severity of ICP were compared and the complications of the patients with different severity of ICP were observed. Results The serum TBA and CG level in the observation group were higher than that in the control group (P<0.05). The serum TBA and CG levels of ICP in the severe ICP group were higher than those in the mild ICP group (P<0.05). The complication rate of severe ICP group was 36.0%, which was higher than that of mild ICP group 15.0% (P<0.05). In the diagnosis of ICP, the sensitivity and specificity of CG TBA were the highest, which were 95.8% and 98.5% respectively. Compared with the healthy pregnancy group, the serum TBA and CG level were significantly increased in the patients with ICP, especially in the patients with severe ICP, and the pregnancy outcome was more poor in the patients with severe ICP. Conclusion The combined screening of serum TBA and CG is of great value in the diagnosis and evaluation of ICP in pregnant and parturient women.
Key Words:Cholic acid; Total bile acid; Intrahepatic cholestasis of pregnancy

基金项目:
作者简介:
参考文献:

[1] 林一,王厚照. 120例ICP患者血清中CG、TBA与TSH水平变化分析[J]. 中国优生与遗传杂志,2014,22(11):128-129.
[2] Goel A, Jamwal KD, Ramachandran A, et al. Pregnancyrelated liver disorders[J]. J Clin Exp Hepatol,2014,4(2):151-162.
[3] 徐凤,程书书,袁明香.妊娠期肝内胆汁淤积症血清生化指标与妊娠结局分析[J]. 中外医学研究,2018,16(2):68-69.

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